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41.
Three engineering treatments were implemented in a driving simulator study to assess the effect of road-based measures on alleviating the symptoms of fatigue. Using results from previous research on the effect of circadian rhythms on fatigue-related crashes, two groups of male drivers were recruited for this study: young shift workers under the age of 35, who attended immediately after their night shift, and older drivers over the age of 45, who completed the study during the ‘post lunch dip’ period, after consuming lunch. Eye tracking (PERCLOS) and lateral driver performance measures were used to assess whether baseline measures of fatigue changed after drivers experienced each of the three treatments, which included variable message signs, chevrons and rumble strips. Results showed a marked difference in these measures between drivers’ baseline (not fatigued) and experimental (fatigued) visits. There were also some reductions in lateral deviation and eye closure (as measured by PERCLOS) when the treatments were encountered, but no marked difference between the three treatments. These results suggest that in addition to driver- and vehicle-based methods currently employed to mitigate the effects of fatigue, the inclusion of such engineering measures may help alleviate fatigue-related impairments in driving, particularly if such treatments are implemented during long stretches of straight monotonous roads which are known to be associated with fatigue-related crashes. However, positive effects of the treatments were short lived, prompting the need for further investigations on their optimal frequency of presentation and combination to achieve maximum impact from these low-cost, road-based treatments. 相似文献
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Ultrastructural and immunohistochemical study of the effect of sodium alendronate in the progression of experimental periodontitis in rats 下载免费PDF全文
Mariana M. Moreira Vivian Bradaschia‐Correa Natasha D. M. Marques Lorraine Braga Ferreira Victor E. Arana‐Chavez 《Microscopy research and technique》2014,77(11):902-909
The aim of the present research was to investigate the ultrastructural aspects and the immunoexpression of receptor activator of NFκB ligand (RANKL) and osteoprotegerin (OPG) on experimental periodontal disease of alendronate (ALN)‐treated rats. Male Wistar rats received daily injections of 2.5 mg/kg body weight of ALN during 7 days previously and 7, 14, and 21 days after the insertion of a 4.0 silk suture into the gingival sulcus around the right upper second molar. Specimens were fixed in 0.1% glutaraldehyde + 4% formaldehyde under microwave irradiation, decalcified in 4.13% EDTA and paraffin embedded for TRAP histochemistry and immunohistochemistry for RANKL and OPG, or embedded in Spurr epoxy resin for TEM analysis. ALN reduced the activity of osteoclasts and significantly decreased the resorption of the alveolar crest. In the control group the alveolar crest appeared resorbed by TRAP‐positive osteoclasts, which presented ultrastructural features of activated cells. The immunoexpression of RANKL was not inhibited by the drug; however, the expression of OPG was increased in the treated animals. The alveolar crest of ALN‐treated specimens at 21 days showed signs of osteonecrosis, like empty osteocyte lacunae, the exposed bone regions and bacterial infection. The results showed that ALN treatment in individuals with periodontal disease represents a risk of osteonecrosis because of the reduced activity of osteoclasts resultant of the increased immunoexpression of OPG. Microsc. Res. Tech. 77:902–909, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
44.
Wu Rachel; Gopnik Alison; Richardson Daniel C.; Kirkham Natasha Z. 《Canadian Metallurgical Quarterly》2011,47(5):1220
In laboratory experiments, infants are sensitive to patterns of visual features that co-occur (e.g., Fiser & Aslin, 2002). Once infants learn the statistical regularities, however, what do they do with that knowledge? Moreover, which patterns do infants learn in the cluttered world outside of the laboratory? Across 4 experiments, we show that 9-month-olds use this sensitivity to make inferences about object properties. In Experiment 1, 9-month-old infants expected co-occurring visual features to remain fused (i.e., infants looked longer when co-occurring features split apart than when they stayed together). Forming such expectations can help identify integral object parts for object individuation, recognition, and categorization. In Experiment 2, we increased the task difficulty by presenting the test stimuli simultaneously with a different spatial layout from the familiarization trials to provide a more ecologically valid condition. Infants did not make similar inferences in this more distracting test condition. However, Experiment 3 showed that a social cue did allow inferences in this more difficult test condition, and Experiment 4 showed that social cues helped infants choose patterns among distractor patterns during learning as well as during test. These findings suggest that infants can use feature co-occurrence to learn about objects and that social cues shape such foundational learning in distraction-filled environments. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
45.
Whipple Natasha; Bernier Annie; Mageau Geneviève A. 《Canadian Metallurgical Quarterly》2011,47(2):396
The aim of this study was to examine the developmental significance of the newly developed dimensional approach to attachment state of mind by investigating its capacity to predict individual differences in the quality of two caregiving behaviors—maternal sensitivity and maternal autonomy support—that are linked to numerous important child outcomes. Seventy-one upper-middle-class, predominantly French-speaking and Caucasian dyads participated in 3 home visits (34 girls). The Adult Attachment Interview (AAI) was administered when the infants were 8 months old, maternal sensitivity was assessed when they were 12 months old, and maternal autonomy support was assessed at 15 months. The results revealed that, above and beyond SES, maternal sensitivity was negatively related to the dismissing dimension of the AAI, whereas maternal autonomy support was negatively linked to the preoccupied/unresolved dimension. In contrast, the traditional AAI categories were not significantly linked to parenting. These results speak to the relevance of using a continuous approach to attachment state of mind when predicting individual differences in specific caregiving behaviors. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
46.
Lante Carbognani Joussef Espidel Natasha Carbognani Leryn Albujas Marisol Rosquete Liakarla Parra Jennifer Mota Anita Espidel Nancy Querales 《Petroleum Science and Technology》2000,18(5):671-699
n-Heptane insoluble contents were determined for an extraheavy-oil vacuum residue, one petroleum and one coal pitch as a function of particle size. This variable was found to affect the yields of insoluble material, aspect which was also observed during extractions carried out with aromatic and halogenated solvents. The precision of results was observed to be independent on the operators. A study was carried out to determine the effect of sample drying time on fraction yields. It was found that maltene fractions were strongly dependent on this variable, whereas asphaltene fractions were totally independent
Predissolution in aromatic solvents proved worthless from the repeatability point of view. However, predissolution of the oil residue in CH2Cl2 followed by filtration and asphaltene precipitation with simultaneous solvent removal, was deemed to be a suitable technique to remove mineral matter and isolate asphaltenes in a single step
Sample oxidation during asphaltene precipitation and isolation was detected by gravimetric and spectroscopic techniques. This fact is very important since common precipitation techniques do not address this issue
Preliminary accelerated extraction experiments carried out with pitch samples at high temperature and pressure, revealed that this approach can be a very interesting research tool to investigate solubility properties. 相似文献
Predissolution in aromatic solvents proved worthless from the repeatability point of view. However, predissolution of the oil residue in CH2Cl2 followed by filtration and asphaltene precipitation with simultaneous solvent removal, was deemed to be a suitable technique to remove mineral matter and isolate asphaltenes in a single step
Sample oxidation during asphaltene precipitation and isolation was detected by gravimetric and spectroscopic techniques. This fact is very important since common precipitation techniques do not address this issue
Preliminary accelerated extraction experiments carried out with pitch samples at high temperature and pressure, revealed that this approach can be a very interesting research tool to investigate solubility properties. 相似文献
47.
Whipple Natasha; Bernier Annie; Mageau Geneviève A. 《Canadian Metallurgical Quarterly》2009,50(4):219
Understanding the intergenerational transmission of attachment patterns has been a main focus of attachment research for many years. Most of the empirical work conducted on this question has addressed maternal sensitivity to infants’ attachment needs. Given that security of attachment is defined as an attachment/exploration balance, some researchers have stressed the need to explore maternal behaviours in the context of infant exploration. The authors propose that self-determination theory (SDT) could contribute to attachment work in this respect given that it has clearly operationalized parental exploration-related behaviours and has related them to numerous child outcomes. This article highlights conceptual, empirical, and methodological parallels that can be drawn between SDT and attachment theory, thus suggesting that they could be complementary on many levels. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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49.
Natasha E. Hatton Dr. Christoph G. Baumann Dr. Martin A. Fascione 《Chembiochem : a European journal of chemical biology》2021,22(4):613-629
During their lifetime almost half of women will experience a symptomatic urinary tract infection (UTI) with a further half experiencing a relapse within six months. Currently UTIs are treated with antibiotics, but increasing antibiotic resistance rates highlight the need for new treatments. Uropathogenic Escherichia coli (UPEC) is responsible for the majority of symptomatic UTI cases and thus has become a key pathological target. Adhesion of type one pilus subunit FimH at the surface of UPEC strains to mannose-saturated oligosaccharides located on the urothelium is critical to pathogenesis. Since the identification of FimH as a therapeutic target in the late 1980s, a substantial body of research has been generated focusing on the development of FimH-targeting mannose-based anti-adhesion therapies. In this review we will discuss the design of different classes of these mannose-based compounds and their utility and potential as UPEC therapeutics. 相似文献
50.
Do Carmo Devaney Ribeiro de Oliveira Denys Ribeiro Barbosa Priscila Fernanda Pereira Godoi Natasha Mirella Inhã 《SILICON》2019,11(6):2961-2974
Silicon - Octa-(3-chloropropyl) octasilsesquioxane (SS) was functionalized with a PAMAM dendrimer (SP) and characterized by some spectroscopic techniques such as Fourier Transform Infrared, Nuclear... 相似文献